Use of LDN in Inflammatory Bowel Disease, Irritable Bowel Syndrome, and Restless Leg Syndrome


Dr Weinstock gives experience with low dose naltrexone for IBS and RLS.

Since 2008, I had been working with a compounding pharmacy on treatments for small intestinal bacterial overgrowth (SIBO). As some patients with SIBO didn’t tolerate the antibiotic erythromycin, I was interested in finding an alternative to assist in enhancing motility. The compounding pharmacy asked if I had heard about low-dose naltrexone (LDN). I hadn’t, so I started looking into it. I found a small paper discussing a potential benefit of LDN on intestinal motility (movement) through its action of blocking opioid receptors (if opioid receptors are overly enervated they inhibit movement). So it seemed theoretically useful. As I began to discover the anti-inflammatory properties of LDN, I also learned that LDN had been shown to be effective in inflammatory bowel disease (IBD) [Crohn’s disease and ulcerative colitis] and irritable bowel syndrome (IBS), so I surmised that it might be useful not only for SIBO, but also for all conditions in which inflammation is a critical issue.

Dr. Weinstock was interviewed by the Low Dose Naltrexone Scientific Organization about his experience with Naltrexone: LDN Science Interviews